The film is a docudrama about cross-dressing and transsexuality, and is semi-autobiographical in nature. Wood himself was a cross-dresser, and the film is a plea for tolerance. It is widely considered one of the worst films ever. However, it has become a cult film due to its low-budget production values and idiosyncratic style.
The Plot:
The movie consists of two parts, the first following a narrator called The Scientist, played by Bela Lugosi, making cryptic comments about humanity. At the beginning of the film proper, Inspector Warren finds the corpse of a male transvestite named Patrick/Patricia, who has committed suicide. Wanting to know more about cross-dressing, Warren seeks out Dr. Alton, who narrates for him the story of Glen/Glenda.
The second part is shorter, following Alan, a pseudohermaphrodite who fights in the Second World War wearing women's underwear. After "his" return, Alan becomes the woman she always was, through surgery. The third part bridges the two stories by returning to Glen/Glenda as he learns the story of Alan/Anne from Dr. Alton (whom Alan/Anne also visited) before managing to cure his transvestism.